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Tag: Treatment Outcome

Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial.

Posted: August 23, 2016 at 11:26 am   /   Degenerative

By most definitions, this is a good  example of a randomized control trial (RCT).  The study populations were well matched and the outcomes were standardly measured.  The follow-up rate was greater than 80%. The inclusion criteria included the presence of back pain (VAS of 5/10 or more),  along with spinal stenosis and up to grade […]

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Minimum 25-year outcome and functional assessment of lumbar discectomy.

Posted: July 12, 2016 at 1:59 pm   /   Degenerative

This paper is a retrospective review on 348 consecutive patients who had lumbar discectomy surgery between 1973 and 1979 by the orthopedic department of Federico II Hospital in Naples, Italy.   Seven different surgeons participated in the surgical treatments.   Two Hundred One (201)  patients agreed to participate in follow-up,  either by mail or by an in […]

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Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study.

Posted: May 26, 2016 at 1:19 pm   /   Degenerative

The debate of surgical management vs. nonsurgical care for the treatment of sciatica resulting from a lumbar disc herniation remains ongoing. This study by Atlas et al (2005) represents a long term prospective investigation looking at the outcomes of surgery vs. conservative treatment up to ten years for patients with sciatica due to a disc […]

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Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.

Posted: February 23, 2016 at 10:45 am   /   Degenerative, General

In 2011, researchers identified the potential for study bias regarding results of the use of Bone Morphogenic Protein-2 for lumbar spinal fusion.   Medtronic, the manufacturer of Infuse BMP-2, consented to have an independent review of their raw data from all FDA rhBMP2 trials.   This study was funded and conducted by The Yale University Open Data […]

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1997 Volvo Award winner in clinical studies. Degenerative lumbar spondylolisthesis with spinal stenosis: a prospective, randomized study comparing decompressive laminectomy and arthrodesis with and without spinal instrumentation.

Posted: December 5, 2015 at 8:23 am   /   Degenerative

This prominent historical study by Fischgrund et al published in 1997, was a well-controlled randomized trial looking at both clinical and radiographic outcomes of lumbar laminectomy with arthrodesis surgery in patients with degenerative spondylolisthesis and spinal stenosis. Patients in this study (N=68) were randomly assigned to two treatment groups; Lumbar laminectomy with posterolateral intertransverse process […]

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Surgery for lumbar spinal stenosis. Attempted meta-analysis of the literature.

Posted: December 5, 2015 at 8:20 am   /   Degenerative, General Spine

This paper published by Turner et al in 1992 represented an attempted meta-analysis  of the literature covering a 24 year period (1996-1990).  Based on the methods described by the authors, 74 studies met the inclusion criteria. One of the major issues in trying to include or exclude studies was a lack of a standardized outcome […]

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2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group.

Posted: December 5, 2015 at 8:09 am   /   Degenerative

This multicenter, randomized control trial out of Sweden was the 2001 Volvo Award Winner in Clinical Studies.   Fritzell et al randomized 294 patients into a surgical treatment group (n=222) versus a non-surgical group (N=72).  Patients were randomly assigned treatment and multiple validated outcome measures were utilized.  The overall goal of the study was to define “if lumbar fusion […]

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Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures.

Posted: December 2, 2015 at 3:39 pm   /   Trauma

Kyphoplasty was first described in 1987. This paper by Lieberman et al was a phase I efficacy study looking at the use of kyphoplasty in the treatment of symptomatic osteoporotic compression fractures. The study included 70 consecutive kyphoplasty procedures in 30 patients over the course of 11 months. Based on a review of the study, […]

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