ISSLS Prize winner: The anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects.
Conventional wisdom states that the mode of failure and cause of disc herniation is secondary to a rupture of nucleus material through the annulus fibrosis. In this paper, the senior author prospectively defined the nature of intraoperatively identified disc herniations in 181 consecutive patients qualified for inclusion. Inclusion criteria included requiring a single level lumbar […]
The natural history of spondylolysis and spondylolisthesis.
This is a classic Spine Study looking at the natural history of spondylolysis and spondylolisthesis in a population of 500 first grade students in a small community bordering New York and Pennsylvania. The initial enrollment period was 1954 to 1957. The inclusion criteria was that the first grader had parental permission and attended one of […]
The prediction of curve progression in untreated idiopathic scoliosis during growth.
The natural history of adolescent idiopathic scoliosis is still not entirely understood despite decades of research. This study by Lonstein and Carlson is truly one of the classic papers published on the subject of idiopathic scoliosis, looking at the prognostic factors related to curve progression. The study population was drawn from a database of juvenile and adolescent […]
Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis.
This study by Hilibrand et al remains one of the most widely cited studies in regarding adjacent segment disease following anterior cervical discectomy and fusion. The study population of 374 consecutive patients (409 fusions) were followed prospectively for the development of adjacent segment disease, as defined by symptomatic radiculopathy or myelopathy, at an adjacent segment […]
Iliac crest bone graft harvest donor site morbidity. A statistical evaluation.
This paper published in 1995 is a case series of 261 patients that have had either posterior or anterior iliac crest harvesting for spinal fusion. With current utilization of bone graft substitutes including bone marrow aspiration and BMP, many of the more recently trained spine surgeons may not have had the experience of dealing with complications and […]