Role of Weekly Teriparatide Administration in Osseous Union Enhancement within Six Months After Posterior or Transforaminal Lumbar Interbody Fusion for Osteoporosis-Associated Lumbar Degenerative Disorders: A Multicenter, Prospective Randomized Study.
With the aging or a population, there has been significant increases in the number of patients receiving lumbar fusion operations secondary to spinal stenosis or spondylolisthesis with spinal stenosis. Unfortunately, bone quality has bearing on the success of lumbar fusions. This paper is a 6 month randomized prospective study on the use of weekly subcutaneous […]
The influence of obesity on the outcome of treatment of lumbar disc herniation: analysis of the Spine Patient Outcomes Research Trial (SPORT).
This publication by Rihn et al represents a retrospective analysis of data collected from the Spine Patient Outcomes Research Trial (SPORT). As has been previously published describing the SPORT trial, participants were either randomized or placed in an observational cohort. This data presented was taken from the as-treated analysis and therefore the randomization effect was […]
The Norwegian Cervical Arthroplasty Trial (NORCAT): 2-year clinical outcome after single-level cervical arthroplasty versus fusion-a prospective, single-blinded, randomized, controlled multicenter study.
This investigation by Sundseth et al presents a prospective randomized study comparing cervical anterior discectomy and fusion (using interbody cage) versus cervical disc arthroplasty in a Norwegian population. Outcomes were determined at 2 years, which is a relatively short time period. Outcome measures included the Neck Disability Index (NDI), SF36, and EuroQol-5D-3L. Overall, this multicenter […]
Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial.
By most definitions, this is a good example of a randomized control trial (RCT). The study populations were well matched and the outcomes were standardly measured. The follow-up rate was greater than 80%. The inclusion criteria included the presence of back pain (VAS of 5/10 or more), along with spinal stenosis and up to grade […]
Frequency and clinical predictors of adverse reactions to chiropractic care in the UCLA neck pain study.
This study by Hurwitz et al from 2005 looked at the type and frequency of adverse events associated with chiropractic treatments for neck pain. Study participants were included if they had neck pain without progressive neurologic deficit or presence of disc herniations. Additionally they were excluded if they had evidence of myelopathy, spondyloarthropathy or were […]
2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group.
This multicenter, randomized control trial out of Sweden was the 2001 Volvo Award Winner in Clinical Studies. Fritzell et al randomized 294 patients into a surgical treatment group (n=222) versus a non-surgical group (N=72). Patients were randomly assigned treatment and multiple validated outcome measures were utilized. The overall goal of the study was to define “if lumbar fusion […]
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