Cell therapy treatments for disc degeneration remains a very exciting area of research. Currently, there are multiple clinics offering forms of these treatments for patients with lower back pain. The science data supporting the use of these techniques remains limited. The Author’s of this paper reviewed Pubmed/MEDLINE data through October 31, 2018, as well as […]
Interspinous process devices(IPD) alone versus decompression surgery for lumbar spinal stenosis(LSS): A systematic review and meta-analysis of randomized controlled trials.
This study was funded by the National Natural Science Foundation of China and represents a systematic review of the literature and meta-analysis of interspinous process devices (IPD) alone versus decompression for lumbar spinal stenosis. The author’s database search found 866 potential articles. IPD devices included X-stop, Coflex, DIAM, Wallis, and Asperious. Studies were included if they […]
Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.
In 2011, researchers identified the potential for study bias regarding results of the use of Bone Morphogenic Protein-2 for lumbar spinal fusion. Medtronic, the manufacturer of Infuse BMP-2, consented to have an independent review of their raw data from all FDA rhBMP2 trials. This study was funded and conducted by The Yale University Open Data […]
This paper published by Turner et al in 1992 represented an attempted meta-analysis of the literature covering a 24 year period (1996-1990). Based on the methods described by the authors, 74 studies met the inclusion criteria. One of the major issues in trying to include or exclude studies was a lack of a standardized outcome […]