Spineopedia Reviewed Contemporary Studies

Cell Therapy for Treatment of Intervertebral Disc Degeneration: A Systematic Review.

Cell therapy treatments for disc degeneration remains a very exciting area of research.  Currently, there are multiple clinics offering forms of these treatments for patients with lower back pain. The science data supporting the use of these techniques remains limited. The Author’s of this paper reviewed Pubmed/MEDLINE data through October 31, 2018, as well as […]

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In Degenerative Spondylolisthesis, Unilateral Laminotomy for Bilateral Decompression Leads to Less Reoperations at 5 Years When Compared to Posterior Decompression With Instrumented Fusion

Patients diagnosed with  degenerative spondylolisthesis patients (DS) and symptomatic lumbar spinal stenosis (LSS) have had standard surgical recommendations of fusion in combination with decompression since the 1990’s.   Since the early 1990’s, surgical techniques have become less invasive.  What traditionally required wide pedicle to pedicle wide laminectomies with partial facetectomies for central stenosis can now be […]

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Aging of the Cervical Spine in Healthy Volunteers A 10-Year Longitudinal Magnetic Resonance Imaging Study

Prospective longitudinal study.  Mean follow-up.  It is 11.7 + .8 years 223 subjects  of original 497 asymtomatic volunteers from asymptomatic volunteers from 1993 to 1996 returned for a repeat MRI more than 10 years after the original MRI.    44.9% Mean age at the time of initial imaging was 39.0 ± 15 years.  At the time […]

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Microsurgical Treatment of Lumbar Disc Herniation: A Report of 158 Patients with a Mean Followup of More Than 32 Years.

This is a retrospective review of reported outcomes of 158 patients,  with a minimum of 25 years followup after microsurgical discectomy of a lumbar herniated disc. The Authors conclude that microsurgical discectomy surgery is an effective technique with high patient satisfaction. This is an important retrospective long term view on microdiscectomy, and certainly is consistent […]

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Interspinous process devices(IPD) alone versus decompression surgery for lumbar spinal stenosis(LSS): A systematic review and meta-analysis of randomized controlled trials.

This study was funded by the National Natural Science Foundation of China and represents a systematic review of the literature and meta-analysis  of interspinous process devices (IPD) alone versus decompression for lumbar spinal stenosis.  The author’s database search found 866 potential articles.  IPD devices included X-stop, Coflex, DIAM, Wallis, and Asperious.  Studies were included if they […]

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The Effects of Smoking and Smoking Cessation on Spine Surgery: A Systematic Review of the Literature.

This systematic review by Jackson and Devine provides us with a current review of the literature in regards to the effects of smoking and smoking cessation on spine surgery.  While this review covers spine surgery in general, our reviewed focused soley on the effects related to cervical disc surgery. There are several potential risks that […]

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The Norwegian Cervical Arthroplasty Trial (NORCAT): 2-year clinical outcome after single-level cervical arthroplasty versus fusion-a prospective, single-blinded, randomized, controlled multicenter study.

This investigation by Sundseth et al presents a prospective randomized study comparing cervical anterior discectomy and fusion (using interbody cage) versus cervical disc arthroplasty in a Norwegian population. Outcomes were determined at 2 years, which is a relatively short time period. Outcome measures included the Neck Disability Index (NDI), SF36, and EuroQol-5D-3L. Overall, this multicenter […]

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Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial.

By most definitions, this is a good  example of a randomized control trial (RCT).  The study populations were well matched and the outcomes were standardly measured.  The follow-up rate was greater than 80%. The inclusion criteria included the presence of back pain (VAS of 5/10 or more),  along with spinal stenosis and up to grade […]

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Surgery for spinal stenosis: long-term reoperation rates, health care cost, and impact of instrumentation.

There has been a significant increase in the rates of spinal fusion in the past 15 years in the United States. This study attempted to identify the efficacy and costs associated with this trend. This study by Lad et al provided a retrospective cohort analysis of a population that underwent spinal stenosis surgery between 2002 […]

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Percutaneous lumbar laser disc decompression: an update of current evidence.

This systematic review by Singh et al (2013) provides an up to date review of the effectiveness of percutaneous lumbar laser discectomy. The acceptance of minimally invasive spine surgery continues to grow from both a demand by patients and amongst surgeons. The goals of having smaller incisions, limiting soft tissue trauma, shorter operating times and […]

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