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Spineopedia Reviewed Contemporary Studies

Interspinous process devices(IPD) alone versus decompression surgery for lumbar spinal stenosis(LSS): A systematic review and meta-analysis of randomized controlled trials.

This study was funded by the National Natural Science Foundation of China and represents a systematic review of the literature and meta-analysis  of interspinous process devices (IPD) alone versus decompression for lumbar spinal stenosis.  The author’s database search found 866 potential articles.  IPD devices included X-stop, Coflex, DIAM, Wallis, and Asperious.  Studies were included if they […]

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The Effects of Smoking and Smoking Cessation on Spine Surgery: A Systematic Review of the Literature.

This systematic review by Jackson and Devine provides us with a current review of the literature in regards to the effects of smoking and smoking cessation on spine surgery.  While this review covers spine surgery in general, our reviewed focused soley on the effects related to cervical disc surgery. There are several potential risks that […]

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The Norwegian Cervical Arthroplasty Trial (NORCAT): 2-year clinical outcome after single-level cervical arthroplasty versus fusion-a prospective, single-blinded, randomized, controlled multicenter study.

This investigation by Sundseth et al presents a prospective randomized study comparing cervical anterior discectomy and fusion (using interbody cage) versus cervical disc arthroplasty in a Norwegian population. Outcomes were determined at 2 years, which is a relatively short time period. Outcome measures included the Neck Disability Index (NDI), SF36, and EuroQol-5D-3L. Overall, this multicenter […]

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Decompression and Coflex interlaminar stabilization compared with decompression and instrumented spinal fusion for spinal stenosis and low-grade degenerative spondylolisthesis: two-year results from the prospective, randomized, multicenter, Food and Drug Administration Investigational Device Exemption trial.

By most definitions, this is a good  example of a randomized control trial (RCT).  The study populations were well matched and the outcomes were standardly measured.  The follow-up rate was greater than 80%. The inclusion criteria included the presence of back pain (VAS of 5/10 or more),  along with spinal stenosis and up to grade […]

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Surgery for spinal stenosis: long-term reoperation rates, health care cost, and impact of instrumentation.

There has been a significant increase in the rates of spinal fusion in the past 15 years in the United States. This study attempted to identify the efficacy and costs associated with this trend. This study by Lad et al provided a retrospective cohort analysis of a population that underwent spinal stenosis surgery between 2002 […]

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Percutaneous lumbar laser disc decompression: an update of current evidence.

This systematic review by Singh et al (2013) provides an up to date review of the effectiveness of percutaneous lumbar laser discectomy. The acceptance of minimally invasive spine surgery continues to grow from both a demand by patients and amongst surgeons. The goals of having smaller incisions, limiting soft tissue trauma, shorter operating times and […]

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Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort.

Mok et al. This recently published, population based cross sectional study by Mok et al, looked at the prevalence and risk factors associated with Modic changes in the lumbar spine among Southern Chinese subjects. This is one of the largest studies in regards to the number of patients included (N=2449) looking at Modic changes.   One […]

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What level of pain are patients happy to live with after surgery for lumbar degenerative disorders?

This study by Fekete et al, which has been approved for publication in The Spine Journal, provided an alternative approach to evaluating clinical outcomes in patients with degenerative lumbar disorders. The study population was derived from a spine surgery outcomes database and EUROSPINE Spine Tango Registry. Over 6900 patients in the database met the inclusion […]

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Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data.

In 2011, researchers identified the potential for study bias regarding results of the use of Bone Morphogenic Protein-2 for lumbar spinal fusion.   Medtronic, the manufacturer of Infuse BMP-2, consented to have an independent review of their raw data from all FDA rhBMP2 trials.   This study was funded and conducted by The Yale University Open Data […]

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ISSLS Prize winner: The anatomy of failure in lumbar disc herniation: an in vivo, multimodal, prospective study of 181 subjects.

Conventional wisdom states that the mode of failure and cause of disc herniation is secondary to a rupture of nucleus material through the annulus fibrosis. In this paper, the senior author prospectively defined the nature of intraoperatively identified disc herniations in 181 consecutive patients qualified for inclusion. Inclusion criteria included requiring a single level lumbar […]

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